Advances in Regenerative Hair Loss Therapies
Autologous regenerative therapies are paving the way for hair restoration by utilizing the body’s own cells to regenerate hair follicles and enhance hair growth.
Mesenchymal, progenitor, and other regenerative cells can transform into different types of cells found in the body. With their capacity to divide and self-renew, they either remain progenitor cells or differentiate into other cell types, restoring specific tissues by replacing damaged ones.
A wealth of research has highlighted that regenerative hair treatments demonstrate high effectiveness in treating various hair loss conditions, including:
- Androgenetic alopecia (male pattern)
- Androgenetic alopecia (female pattern)
- Alopecia areata (in a stabilised stage)
- Scarring alopecia (where hair follicles are destroyed and replaced by scar tissue)
How Regenerative Cells Work
Autologous cellular mesotherapy treatments leverage autologous tissues to create a suspension (aqueous mixture) rich in mesenchymal cells and stromal vascular fraction (SVF). The micrografts obtained contain these regenerative cells, growth factors and other bioactive substances that contribute to tissue regeneration.
Key Components of Regenerative Cells
- Mesenchymal Cells: Found in bone marrow and adipose tissue, these cells can transform into those that renew skin tissues, hair follicles, and other structures. They enhance cell growth, reduce inflammation, and accelerate tissue healing.
- Stromal Vascular Fraction (SVF): Found in adipose tissue, SVF is rich in mesenchymal, endothelial, and other supportive cells that improve the nutrient supply to hair follicles and aid in repairing scarred areas.
A major advantage of autologous cellular therapy compared to traditional treatments such as PRP or pharmacological therapies is its potential effectiveness even in advanced stages of alopecia.
Autologous Therapy in Hair Transplantation
Micrografts are injected into the scalp during hair transplantation procedures. It is important to clarify that cellular therapy does not replace hair transplantation but enhances its outcomes. Studies have shown that hair transplants combined with autologous cellular technology result in significantly healthier scalp conditions, denser hair growth, and faster recovery times than conventional methods.
Regenerative cells’ ability to reduce hair loss post-transplantation is remarkable. This phenomenon, known as “shock loss,” is a natural, temporary shedding of transplanted hair following surgery. The treatment also helps minimise postoperative inflammation and accelerates healing in donor and recipient areas.
Comparative Evaluation of PRP and Cellular Therapies
While both cellular therapies and platelet-rich plasma (PRP) treatments aim to stimulate hair growth, autologous cell-based therapies offer a more advanced approach by incorporating mesenchymal cells and SVF, which possess superior regenerative properties.
| Treatment | PRP (Platelet-Rich Plasma) | Cellular Therapies |
|---|---|---|
| Mechanism of Action | Stimulates follicles with growth factors. | Restores follicle function through regeneration of damaged tissues and angiogenesis (Fukuoka et al., 2015). |
| Effectiveness | 19% increase in hair densit in 6 months (AEDV, Actas Dermo, 2020) | 29% increase in hair density in 6 months (Gentile et al., 2017). |
| Application Scope | Ideal for early to moderate androgenetic alopecia. | Effective even in severe cases, including autoimmune conditions and scarring alopecia (Kwon, H. et al, 2023). |
| Duration of Results | Temporary, requiring repeat sessions every 6-12 months. | Long-lasting results with reduced need for repeat treatments. |
| Anti-Inflammatory Action | Limited. | Strong, suitable for inflammatory conditions. |
| Treatment Time | 1 hour per session. | 1-2 hours for the procedure. |
| Cost | Low initial cost but increases with repeat sessions. | Higher initial cost but more cost-effective in the long run. |
For individuals with androgenetic alopecia, injecting autologous activated regenerative cell mixtures into thinning areas stimulates dormant follicles, regenerates damaged ones, and enhances scalp health and natural hair growth. The ability of regenerative cells to prolong the hair growth phase ensures long-term results.
The non-invasive nature of this treatment and minimal recovery time makes it an ideal option for those seeking effective therapy without surgical intervention. The role of SVF in angiogenesis further supports nutrient delivery and blood flow to the scalp, addressing one of the primary causes of hair thinning.
Recent Advances in Autologous Cellular Technology
In February 2025, at the ASHRS Hair Restoration Surgery Conference in Cairo, the G-CELL device was presented to the scientific community, coordinated by Dr Anastasios Vekris, President and Scientific Director of Advanced Hair Clinics. This technology, developed by Global Biyomedikal, paves new paths in autologous cellular therapies and regenerative medicine.
G-CELL stands out with its autologous micrograft SVF technology compared to conventional regenerative therapies.
What is Stromal Vascular Fraction (SVF)?
Stromal vascular fraction (SVF) is widely used in medicine for orthopaedic conditions and tissue healing. Its rich cellular composition has also proven effective in treating hair loss and promoting hair regeneration.
It contains:
- Mesenchymal Progenitor Cells: Regenerative cells that contribute to tissue repair.
- Endothelial Cells: Support angiogenesis and tissue oxygenation.
- Pericytes: Help stabilise blood vessels and regulate blood flow.
- Macrophages and Other Immune Cells: Reducing inflammation and modulating the local immune response.
Essentially, SVF acts as a “biological mechanism” that combines regenerative and supportive cells to enhance tissue regeneration.
How G-CELL Therapy Works
The procedure is similar to PRP therapy, with the key difference being that tissue samples are used instead of platelets.
- Tissue Collection: Under local anaesthesia, 3-4 small tissue samples are taken via punch biopsy from the posterior scalp or with a cannula from the abdomen. These samples are mixed with saline to maintain viability.
- Micrograft Separation: The micrografts are isolated through centrifugation, creating an SVF-enriched aqueous suspension.
- Homogenisation: The mixture is homogenised to ensure uniform distribution of regenerative cells and maximise efficacy.
- Photoactivation: The suspension is exposed to red LED light, enhancing its regenerative properties.
- Application: The processed micrograft suspension is injected into strategic areas of the scalp to optimise follicular impact and improve scalp health.
As research into regenerative cells continues, the development of devices such as G-CELL is expanding the potential of regenerative medicine. These devices simplify treatment procedures and make them more accessible than conventional autologous cellular therapies.
Next Steps in Autologous Cellular Therapy
Autologous cellular therapies transform hair transplantation and hair loss treatment, delivering superior results to conventional approaches like PRP and pharmaceutical solutions. Ongoing research and clinical advancements continue to expand the frontiers of natural hair regeneration, paving the way for more precise and effective patient treatment options.
Why Choose Us for Hair Loss Treatment
If you are experiencing hair loss or are considering a hair transplant, we offer a comprehensive range of solutions to restore your hair. Book an appointment today and discover how you can achieve thicker, healthier hair with a personalised and effective treatment plan tailored to your unique needs. Please leave us a message below or call us from Greece at (+30) 210 6980451 and from Cyprus at (+357) 25251040 for Limassol and (+357) 22257490 for Nicosia.
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